Noradrenaline Trifluoroacetate EP Impurity G CAS 13062-58-3(Free Base)
| CAS No. | 13062-58-3(Free Base) |
| Molecular Formula | C22H21NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Noradrenaline Trifluoroacetate EP Impurity G.
Noradrenaline Trifluoroacetate EP Impurity G (CAS 13062-58-3(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21NO3C2HF3O2 and a molecular weight of 461.44 g/mol.
Noradrenaline Trifluoroacetate EP Impurity G (C22H21NO3C2HF3O2) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21NO3 C2HF3O2 |
| Molecular Weight | 461.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Noradrenaline Standards
- L-Noradrenaline Bitartrate Monohydrate (CAS 108341-18-0)
- Noradrenaline Hydrochloride EP Impurity F (CAS 20455-68-9)
- Noradrenaline Hydrochloride EP Impurity B (CAS 5090-29-9)
- l-Noradrenaline tartrate (CAS 51-40-1)
- L-Noradrenaline (CAS 51-41-2)
- Noradrenaline EP Impurity E (CAS 54234-59-2)
- Noradrenaline(Norepinephrine) Impurity 68 (CAS 67083-58-3)
- Noradrenaline bitartrate (CAS 69815-49-2)
Recommended Standards
- Formoterol Impurity 23 (CAS 43229-01-2)
- Nerandomilast impurity 7 (CAS CATO-C4X-34737)
- Azelastine Impurity 17 (CAS 1239312-56-1)
- 10-Benzyl-2,3-dihydroimidazo[2,1-b]quinazolin-5(10H)-one (CAS 31007-41-7)
- (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-((8-methoxypyrimido[5,4-d]pyrimidin-4-yl)amino)tetrahydrofuran-3,4-diol (CAS 118515-48-3)
- TAE 684 (CAS 761439-42-3)
- Ethyl 4-amino-3-bromo-5-fluorobenzoate (CAS 1160574-67-3)
- Olanzapine Impurity 29 (CAS 59591-86-5)
- 2-(2-Chlorobenzyl)-1H-pyrrole (CAS 1706460-18-5)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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